We have insufficient evidence to make a recommendation for use in out-patient settings.
Mild infection
- Symptomatic (any acute COVID-19 related symptoms
- AND respiratory rate <24/min
- WITHOUT pneumonia or hypoxia
We do not recommend use of Colchicine in those hospitalized with COVID-19(strong recommendation)
Mild or moderate illness without hypoxia
- Pneumonia (clinical or radiological)
- AND respiratory rate ≤30/min
- AND SpO2 ≥94% on room air
Moderate illness with hypoxia
NO features of severe or critical illness (see below).
- Hypoxia (SpO2 <94% on room air)
- AND respiratory rate ≤30/min
- AND SpO2 ≥90% on room air
Severe infection
Pneumonia with ANY ONE of the following:
- respiratory rate >30/min
- severe respiratory distress
- SpO2 <90% on room air
- NO invasive or non-invasive respiratory support needed
Critical infection
- Requirement for high-level respiratory support: non-invasive ventilation, high-flow oxygen (≥20 litres per minute) or invasive mechanical ventilation
- OR acute respiratory distress syndrome (PaO2/FiO2 ratio of <300)
- OR sepsis
- OR shock