| Prophylactic dose (Non-therapeutic) anticoagulation | |
| Low molecular weight heparin (LMWH) | Enoxaparin 40mg Q24H (or equivalent dose of other LMWH); increase to 40mg Q12H if BMI >40 or weight >120 kg |
| Unfractioned heparin (UFH) | 5000 Units Q12H |
Definition of moderate illness:
- Pneumonia (clinical or radiological) OR hypoxia (SpO2 <94% in adults with no underlying lung disease)
- AND respiratory rate ≤30/min
- AND SpO2 ≥90% on room air
Definition of Severe illness
Pneumonia with ANY ONE of the following:
- severe respiratory distress or respiratory rate >30/min
- SpO2 <90% on room air
- NO invasive or non-invasive respiratory support needed
Definition of critical:
- Requirement for high-level respiratory support: noninvasive ventilation, high-flow oxygen (≥20 litres per minute) or invasive mechanical ventilation
- OR acute respiratory distress syndrome (PaO2/FiO2 ratio of <300)
- OR sepsis
- OR shock
Definitions:
| Therapeutic dose anticoagulation | |
| Low molecular weight heparin (LMWH) | Enoxaparin 1mg/kg Q12H (or equivalent dose of another LMWH) |
| Unfractioned heparin (UFH) | 80 U/kg bolus, followed by 18U/kg/hr infusion [Targeting APTT of 55-75 seconds] |
| Prophylactic dose (Non-therapeutic) anticoagulation | |
| Low molecular weight heparin (LMWH) | Enoxaparin 40mg Q24H (or equivalent dose of other LMWH); increase to 40mg Q12H if BMI >40 or weight >120 kg |
| Unfractioned heparin (UFH) | 5000 Units Q12H |
Mild illness:
NO features of severe or critical illness (see below).
• Symptomatic (any acute COVID-19 related symptoms)
• AND respiratory rate <24/min
• WITHOUT pneumonia or hypoxia
Moderate illness without hypoxia:
NO features of severe or critical illness (see below).
• Pneumonia (clinical or radiological)
• AND respiratory rate ≤30/min
• AND SpO2 ≥94% on room air
Definitions
| Therapeutic dose anticoagulation | |
| Low molecular weight heparin (LMWH) | Enoxaparin 1mg/kg Q12H (or equivalent dose of another LMWH) |
| Unfractioned heparin (UFH) | 80 U/kg bolus, followed by 18U/kg/hr infusion [Targeting APTT of 55-75 seconds] |
Moderate illness with hypoxia
NO features of severe or critical illness (see below).
- Hypoxia (SpO2 <94% on room air)
- AND respiratory rate ≤30/min
- AND SpO2 ≥90% on room air
Severe illness:
Pneumonia with ANY ONE of the following:
- Respiratory rate >30/min
- Severe respiratory distress
- SpO2 <90% on room air
- NO invasive or non-invasive respiratory support needed
A conditional recommendation is one for which the desirable effects probably outweigh the undesirable effects (weak recommendation FOR an intervention) or undesirable effects probably outweigh the desirable effects (weak recommendation AGAINST an intervention) but appreciable uncertainty exists. This implies that not all will be best served by this recommendation and decisions can be made by the patient and caregiver based on patient values, resources and setting with a clear understanding of the ensuing harms and benefits.
Definitions:
| Therapeutic dose anticoagulation | |
| Low molecular weight heparin (LMWH) | Enoxaparin 1mg/kg Q12H (or equivalent dose of another LMWH) |
| Unfractioned heparin (UFH) | 80 U/kg bolus, followed by 18U/kg/hr infusion [Targeting APTT of 55-75 seconds] |
| Prophylactic dose (Non-therapeutic) anticoagulation | |
| Low molecular weight heparin (LMWH) | Enoxaparin 40mg Q24H (or equivalent dose of other LMWH); increase to 40mg Q12H if BMI >40 or weight >120 kg |
| Unfractioned heparin (UFH) | 5000 Units Q12H |
Critical illness:
- Requirement for high-level respiratory support: noninvasive ventilation, high-flow oxygen (≥20 litres per minute) or invasive mechanical ventilation
- OR acute respiratory distress syndrome (PaO2/FiO2 ratio of <300)
- OR sepsis
- OR shock