Anti-Coagulation- Recommendations – V2

HOSPITALISED WITH MILD OR MODERATE ILLNESS WITHOUT HYPOXIA

STRONG RECOMMENDATION FOR PROPHYLACTIC DOSE ANTICOAGULATION

Definitions:

Prophylactic dose = ....

Mild illness

NO features of severe or critical illness (see below).

  • Symptomatic (any acute COVID-19 related symptoms)
  • AND respiratory rate <24/min
  • WITHOUT pneumonia or hypoxia

Moderate illness without hypoxia

NO features of severe or critical illness (see below).

  • Pneumonia (clinical or radiological)
  • AND respiratory rate ≤30/min
  • AND SpO2 ≥94% on room air
NO RECOMMENDATION FOR/AGAINST THERAPEUTIC DOSE ANTICOAGULATION

Definitions:

Therapeutic dose = ....

Mild illness

NO features of severe or critical illness (see below).

  • Symptomatic (any acute COVID-19 related symptoms)
  • AND respiratory rate <24/min
  • WITHOUT pneumonia or hypoxia

Moderate illness without hypoxia

NO features of severe or critical illness (see below).

  • Pneumonia (clinical or radiological)
  • AND respiratory rate ≤30/min
  • AND SpO2 ≥94% on room air

HOSPITALISED WITH MODERATE ILLNESS WITH HYPOXIA

STRONG RECOMMENDATION FOR AT LEAST PROPHYLACTIC DOSE ANTICOAGULATION

Definitions:

Prophylactic dose = ....

Moderate illness with hypoxia

NO features of severe or critical illness (see below).

  • Hypoxia (SpO2 <94% on room air)
  • AND respiratory rate ≤30/min
  • AND SpO2 ≥90% on room air
CONDITIONAL RECOMMENDATION FOR THERAPEUTIC DOSE ANTICOAGULATION

Definitions:

Therapeutic dose = ....

Mild illness

NO features of severe or critical illness (see below).

  • Symptomatic (any acute COVID-19 related symptoms)
  • AND respiratory rate <24/min
  • WITHOUT pneumonia or hypoxia

Moderate illness without hypoxia

NO features of severe or critical illness (see below).

  • Pneumonia (clinical or radiological)
  • AND respiratory rate ≤30/min
  • AND SpO2 ≥94% on room air

HOSPITALISED WITH SEVERE ILLNESS

STRONG RECOMMENDATION FOR AT LEAST PROPHYLACTIC DOSE ANTICOAGULATION

Definitions:

Prophylactic dose = ....

Definition of severe:

Pneumonia with ANY ONE of the following:

  • respiratory rate >30/min
  • severe respiratory distress
  • SpO2 <90% on room air
  • NO invasive or non-invasive respiratory support needed
CONDITIONAL RECOMMENDATION FOR THERAPEUTIC DOSE ANTICOAGULATION

Definitions:

Therapeutic dose = ....

Definition of severe:

Pneumonia with ANY ONE of the following:

  • respiratory rate >30/min
  • severe respiratory distress
  • SpO2 <90% on room air
  • NO invasive or non-invasive respiratory support needed

HOSPITALISED WITH CRITICAL ILLNESS

STRONG RECOMMENDATION FOR PROPHYLACTIC DOSE ANTICOAGULATION

Definitions:

Prophylactic dose = ....

Definition of critical:

  • Requirement for high-level respiratory support: noninvasive ventilation, high-flow oxygen (≥20 litres per minute) or invasive mechanical ventilation
  • OR acute respiratory distress syndrome (PaO2/FiO2 ratio of <300)
  • OR sepsis
  • OR shock
NO RECOMMENDATION FOR/AGAINST THERAPEUTIC DOSE ANTICOAGULATION

Definitions:

Therapeutic dose = ....

Definition of critical:

  • Requirement for high-level respiratory support: noninvasive ventilation, high-flow oxygen (≥20 litres per minute) or invasive mechanical ventilation
  • OR acute respiratory distress syndrome (PaO2/FiO2 ratio of <300)
  • OR sepsis
  • OR shock